Yes, Multisite install, custom theme, lots of plugins.
Of the plugins, the most likely to conflict may be Advanced Access Manager, since it also deals with user/role access control? I’m using it to hide all config/profile panels for Subscribers, forcing them to stay in the frontend.
With Multisite, it took a little fiddling around to figure out which Admin login had the right view and permissions for multirole config. But what I’m looking for, ideally, is auto-logout for any Subscriber, no auto-logout for any Administrator.