The biggest issue is the loading time of the backend. Customers are experiencing 5 to 10 times the waiting time (+20 seconds) before a page is loaded. Logging in takes a while too. Weve played with object cache to optimize but that did not do a lot.
Our customers exploit light weight sites, 99% text, no heavy content, CND, so this would not be the problem. Besides that, they are all hosted at a 100% wordpress hoster, the best in Europe, on a VPS.
We have continued the testing and will let you know some results.