Noticed, that i had WooCommerce, and just updated tothe latest available, and most of the issues vanished.
I do have HTTP Request whitelisting, and other thingys running, but they never caused issues like these.
Now i’ve enabled Cloudflare Cache in developer mode, Flushed Litespeed Web Cache from server and restarted REDIS CACHE on the server, also revisited PHP memory per script, so now it sems working again.