I recently installed APC and was getting white screen of death. Thanks to input in this thread, I resolved it by setting apc.include_once_override=0
I also updated to the latest version of APC using PECL, although I cannot say that I saw anything relevant to the wp issue in the release notes.
FYI – I’m running Ubuntu 5.2.6-3ubuntu4.6, APC 3.1.6 and WP 3.0.4
Danny Lieberman