As and experiment, I added a few lines to the “WP Offload S3 Lite” code (my DO Space URL/region but hardcoded) and replaced AWS access keys by DigitalOcean keys directly in the WP options table, and found out in result the plugin works with DO Spaces: files copied to Spaces, image URLs replaced.
So, looks there are no critical obstacles for adding support of DigitalOcean Spaces but some extra work. Deliciousbrains, please do it!