WP as a CMS – Can it handle this?

Greetings;

I’m embarking on a project where the client wants a CMS designed in WordPress. (I’m fairly new, and primarily a WP developer)

Here are some requirements we’re looking to incorporate:
1) User credentials. We may have members who have access to rich content, non-members, University Affiliates who can modify some region of the web space to show off their content. This would be in addition to external links.

2) Host a database. Qualified, registered users should be able to enter content for their organizations. This should be searchable with limits depending on the credentials of the user.

3) Probably some area where there may be a wiki that qualified registered users can work together on a given project.

4) Some kind of blog and/or discussion area. This could be outsourced to a standard blog program.

5) Video hosting. I anticipate having a library of lectures that may have associated papers and/or powerpoints. Depending on credentials users may have full or partial access. Robust video hosting is required, but may not necessarily be part of this site.

Have you ever encountered a WP project with such robust interface requirements? I am anticipating writing a Form in which each user can enter data that will be stored and searchable.

I’m ready to try to tackle it in WP. Any suggestions?