Unable to upload images on large multisite installs

I’m not sure that is possible, some images just take a long time to optimize, or are you seeing something specific where you think we’re grabbing options from every site?

Just to be sure, I went through the areas where EWWW does loop through every site, and none of those trigger on an optimization. One is for removing scheduled tasks when the relevant options get saved, another is for calculating the savings across all sites, and the last is on plugin deactivation.

Assuming you have this activated network-wide, I might be able to offer some advice on speeding things up if you enabled debugging and post the debug information from the settings page.