Multi-Column Theme That Displays Content in Columns Based on Category

I’m the hunt for a specific type of theme that I haven’t yet come across, and I was hoping some resident sages may offer some suggestions.

THE GIST
I’m looking for a multi-column theme that will display posts in multiple columns, dependent upon the category assigned to the post.

EXAMPLE
Let’s say we have a three-column theme that has 1) a sidebar, 2) content column A, and 3) content column B. Anything I post in categories W and X automatically goes into column A, and all posts in categories Y and Z appear in column B. Does any such beast exist?

WHY
Let’s say I have two types of posts–regular length and short, twitter-like posts. I’d like to separate the columns in which those posts appear, and I’d like to control the column in which they appear by the category I assign to them.

FURTHER
More than two content columns and the ability to easily change the width of said columns.

Thanks for your help!