I think: It depends on who and how setup the server and cache system.
W3 Total Cache can setup with Varnish, or with Varnish and Memcached too, also with Redis!
I have some experience with (W3 Total Cache/Varnish) and (W3 Total Cache/opcache), both of them had a very good result.
Totally, it depends on who and how setup them ??