I am looking to turn off the reply option on my responsive theme blog.
From your WordPress admin dashboard, go to Settings > Discussion and uncheck the box that’s labeled Allow people to post comments on new articles.
Also can I change the color/style of text in html in the widget area
Yes, but you should learn to use a web debugging tool like Firebug (a free extension for Firefox) or Chrome Developer Tools, which comes built-in with Chrome. Once you figure out what CSS to use, you can add it through the Responsive theme’s custom CSS option: go to Appearance > Theme Options, expand the CSS Styles section, and enter your CSS rules in the Custom CSS Styles field. If you do not understand CSS, there is a good tutorial here.