problem

I get this on page when I try to go to set up blog – what am I doing wrong and what do I have to do.

Warning: main(/webroot/c/u/cultur1/www/blog/wp-includes/wp-db.php) [function.main]: failed to open stream: No such file or directory in /webroot/c/u/cultur1/www/blog/wp-settings.php on line 100

Fatal error: main() [function.require]: Failed opening required ‘/webroot/c/u/cultur1/www/blog/wp-includes/wp-db.php’ (include_path=’.:/usr/share/php4:/usr/share/php’) in /webroot/c/u/cultur1/www/blog/wp-settings.php on line 100