Post page settings importance

Does leaving ‘Post page’ in the WordPress ‘Reading Settings’ options blank cause any issues? For example, do other plugins, APIs, or external services or search engines reference this in any way? Would there be any negative effects if I constructed a theme in a way that prevented this being set.

My original post was locked as it was believed to be a question I should direct at my premium theme support, however, I was simply giving context to a general question regarding the importance of this setting.