Before this update, my only problem was that enabling HTTP compression caused my site to render without any styles. This issue is now fixed for me, and my Page Speed score is back up to 97/100. (Thank you Mr. Townes!)
Others have mentioned this, but I’ll reiterate:
1. Change your settings to what you need, and click one of the blue “Save all settings” buttons.
2. Click the “Deploy” button at the top of the page.
3. Go to the “General” settings page, and click the “empty all caches” button.
As for the warning boxes (outlined in pink/red) that say “You do not have [blah blah] enabled…”, I just ignored them.