Nextgen 2.0 Imsanity

NextGen has their own upload functionality outside of WordPress’s API so there’s no way to support it without customizing code specifically for their plugin (if that is even possible). The best solution would be to ask the NextGen authors to add the following code to the end of their upload function:

// see wp-admin/includes/file.php function wp_handle_upload for info on what $struct should contain
return apply_filters( 'wp_handle_upload', $struct, 'upload' );

If they would add that, then NextGen would support all image plugins, including Imsanity.