newsletter plugins for multi site setup

I’m running a multisite setup for a number of local cookery schools. Each school has their own blog to give details of events in their area. I’d like to setup the ability for users to register against each local site and to receive a newsletter/targeted email for the local school.
I’ve tried a number of newsletter and email plugins but they have all seemed to only work for the super admin. Are there any plugins that work well with a multi site setup?