Help in editing theme file – how do i have sperate page for homepage?

Hi,

Can anyone please with a template were-in i need to show multiple sections on homepage. Homepage should look different from the other pages.

How do i go about editing the theme index file? It starts with header, below that slide show, below that a large banner, then within few of the sections, i need to have widgets like music track list, music artist and youtube video plugin.

Thank you.