Files uploaded with wp_handle_upload not added to CDN

New media items uploaded with wp_handle_upload do not get uploaded to the S3 bucket but the URL is replaced on the front end, resulting in a 404.

Has anyone done the legwork of figuring out how to tell W3TC to handle the upload to S3 for items uploaded with wp_handle_upload() or media_handle_upload()?

Or stepping back a moment, I have ACF fields containing URLs of media that users upload from the front end. Is there an way I can tell W3TC, “Here is a file field from an HTTP POST. Send it to S3 and give me the URL.”

Thanks!

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