Exclude Internet Explorer

Hi,
is it possible to constrain cache creating to visits with non-IE browsers?
Can I exclude all versions of Internet Explorer? What string should I use in the exclude rule?

Background:
I use a child theme to “twenty twenty one”. “twenty twenty one” loads CSS conditionally – either an IE version or another one for all other browsers. If the cache of a page is created on a visit with an IE browser all other visitors get the IE styles too which leads to noticeable differences in the layout.

Thank you,
Andrea