Custom theme advice

Hi All,

I am new to this forum. The reason I joined is I have decided to use WP as a quick solution for a CMS. I basically have to put together I basic CMS to manage news and job vacancies here at work. I put together a mockup of the site and am struggling to find any tutorials on the web that thoroughly explains the process of implementing a custom skin. I am planing on building this using css/xhtml. Can someone advise or point me in the right direction to info that can help me integrate WP.

Thanks,
stoney.