Hi @wordpressrun! L&L does give you the tools to build entire page layouts that apply to certain parts of your site using L&L. L&L isn’t a page builder though, so those layouts would need to be built in the L&L template editor in HTML and noting Gutenberg or another page builder as you’ve suggested. L&L integrates natively with Gutenberg, Elementor, and Beaver Builder though so you could lay out your content and apply it to certain pages using something like Beaver Themer and just use L&L to display dynamic content from your ACF fields as needed.
One thing to keep in mind when reading through the Loops & Logic documentation or blog posts about L&L is that the term “template” in the context of L&L differs from the term “template” used by WordPress. In L&L, a template is the unique post type created by the plugin and when you write L&L markup, it always needs to be written inside a template post.
If you want to go fully manual use L&L to build a page layout that applies to certain types of pages and uses dynamic content from ACF, you can certainly do that (we’ve done it on many of our own sites). To do that, in your WP admin, head to Tangible > Layouts > Add New > Location and you’ll be able to set location rules as to where you’d like your template to run.
As far as a step-by-step guide, you might want to check out this beginner’s guide as well as some of the other posts on that blog to get a grasp of how you can get started with L&L.
By the way, I thought I’d mention that you might find the Loops & Logic forum to be a better place to get product support in the future. It’s a much more active community than this support in the WordPress plugin repository.