Just catching up with support threads…
Oenology is actually a bit of a balance between an unstyled Theme like Toolbox, and a turnkey Theme like Twenty Twelve. Oenology has plenty of template hooks and custom filters to enable you to modify almost everything, but does make some basic layout assumptions.
It comes with several color schemes (called “varietals”), one of which, Cuvee, would be suitable for completely re-skinning the Theme, as it defines a minimum amount of CSS. (Though, the “varietals” are also extensible via custom filters, as well.)
Basically, let me know how you’d like to extend/modify Oenology, and I’ll try to show you how to do it.