auto update to 3.3.2 wordpress

trying to update new version but keep getting this message:

Warning: copy(/homepages/0/d410448791/htdocs/app410448804/wp-admin/includes/update-core.php) [function.copy]: failed to open stream: Permission denied in /homepages/0/d410448791/htdocs/app410448804/wp-admin/includes/class-wp-filesystem-direct.php on line 200
Could not copy files.

Installation Failed Any one with any help would be great, have tried deactivating plug ins but still no good