I’m a big fan of this horizontal approach, which I’ve now seen done well on quite a few sites, including yours. That said, here’s some nit-picking:
The middle section could do with something more to draw me in – at the moment it is considerably smaller, with just the excerpt, than the header and footer sections.
Links all behave differently on the front page – in the content, two of the links lose the text-decoration on hover, and one has no change. In the footer, in three places the text-decoration goes, but in the previous posts , there’s only a slight, and almost unnoticeable colour change. (I like the method of losing the underline when hovering over a link rather than the other way round, btw)
In the header, when you hover over a menu tab next to the currently active one, you end up with two large blocks of white with no gap between. Perhaps it’s a very personal preference, but a small border to break these up would look better.
But as I said, mere nit-picks.