@duttaanimesh40gmailcom Although Asset CleanUp deactivates functions such as minify/combine CSS/JS when other plugins are already having them turned ON, you still need to be careful not to mix functionalities.
Asset CleanUp has had issues with Autoptimize having “Minify HTML” turned on as reported by other users in this forum. Not everyone is having this issue, but it happens in some environments, so you need to be careful with that.
Many users have WP Fastest Cache and Asset CleanUp enabled and that’s all they need. It all depends on your needs. If you feel there’s a feature that is missing and only WP Optimize (for instance) has it, then you can use all three as long as you do it wisely. For instance, page caching which is supported by both WP Optimize and WP Fastest Cache should not be enabled in both plugins.
As a rule of thumb, the fewer performance plugins a website uses, the better as things are easier to manage, at least for the regular user that is not very technical.